Characterization of Fibronectin-Related Substances in Normal and Passive Heymann Nephritis Rats.
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چکیده
منابع مشابه
Role of xanthine oxidase in passive Heymann nephritis in rats.
Passive Heymann nephritis (PHN) in rats is a model of human membranous nephropathy characterized by formation of subepithelial immune deposits in the glomerular capillary wall and complement activation. Oxygen radicals have been implicated in the subsequent glomerular damage which leads to proteinuria. This study examines the involvement of xanthine oxidase in this process. Xanthine oxidase act...
متن کاملImmune Deposit Formation in Passive Heymann Nephritis
Immunologic mechanisms leading to the deposition of immune complexes in glomeruli are the main causative factors in many renal diseases . Little is known, however, about the molecular mechanisms responsible for the accumulation of immune deposits (IDs)' in the glomerulus. To gain insights into this problem we have been studying the formation of IDs in Heymann nephritis (HN), an experimental mod...
متن کاملImmune Deposit Formation in Passive Heymann Nephritis
Immunologic mechanisms leading to the deposition of immune complexes in glomeruli are the main causative factors in many renal diseases . Little is known, however, about the molecular mechanisms responsible for the accumulation of immune deposits (IDs)' in the glomerulus. To gain insights into this problem we have been studying the formation of IDs in Heymann nephritis (HN), an experimental mod...
متن کاملA synthetic heparanase inhibitor reduces proteinuria in passive Heymann nephritis.
The beta-D-endoglycosidase heparanase has been proposed to be important in the pathogenesis of proteinuria by acting to selectively degrade the negatively charged side chains of heparan sulfate proteoglycans (HSPG) within the glomerular basement membrane (GBM). A loss of the negatively charged HSPG may result in alteration of the permselective properties of the GBM, loss of glomerular epithelia...
متن کاملReduction of protein excretion by dimethyl sulfoxide in rats with passive Heymann nephritis.
Passive Heymann nephritis, a model of immune complex nephritis, was produced in rats by injection of rabbit antibrush border membrane vesicle antibodies to examine the effect of treatment of epimembranous glomerulonephritis with dimethyl sulfoxide. Administration of DMSO twice a day, 5 days a week for 4 weeks significantly reduced protein excretion in the autologous phase of the model. This ben...
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ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1998
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.21.429